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Argireline® A Botox Alternative


Argireline® is a powerful anti-wrinkle hexapeptide with a Botulinum Toxin-inspired activity. It has become one of the most sought after anti-aging agents on the market. Argireline’s purpose is to decrease the visible effects of aging by reducing the deep wrinkles and lines that occur around the forehead, mouth and eyes.

Argireline®, which goes under the scientific name of Acetyl Hexapeptide-8, is manufactured by Lipotec. Lipotec is a Barcelona-based cosmetics research lab. It is interesting to note that some of the products that feature Argireline® as an active ingredient also sell themselves as “made in the USA,” neglecting the fact that Argireline’s real point of origin is in Europe.

So what’s so great about Argireline?

The peptide is derived from natural proteins that actually relax facial muscles to the point of paralysis. This goes well with the company’s “like Botox without the hassle”. Relaxed facial muscles will minimize current wrinkles caused by repetitive muscle contractions, as well as prevent new wrinkles. Muscle contractions are guided by a chemical reaction called the “SNAP receptor complex,” and Argireline is specifically designed to interfere with this reaction.

Chemically, when applied as a solution to specific areas of the face, Argireline inhibits the reactions that cause muscles to move or contract - for example when forming facial expressions such as smiling or frowning.

Repetitive muscle movements create lines and wrinkles and it is believed the attenuation of muscular contractions can reduce the depth of existing wrinkles and prevent the formation of new lines. The reduction in muscle movement caused by Argireline has been shown to produce an anti-aging effect.

It is a safer, cheaper, and milder alternative to Botulinum Toxin A (Botox), because the principles behind their chemical actions are similar. However, the small amounts of Argireline® used in cosmetics make it a much milder alternative. It also works very differently because it is administered externally to the skin through creams and does not require injection.

Studies with human volunteers show that Argireline® delivers superior anti-wrinkle results, with the severity of wrinkles around the eyes decreased up to 17% after 15 days of treatment and up to 27% after 30 days of treatment. This represents a breakthrough in cosmetic science because of its remarkable speed in anti-wrinkle activity.

Both in vitro and in vivo methods of testing have been used; the in vitro testing confirmed the mechanism by which Argireline® is thought to modulate wrinkles, whereas the in vivo testing was used to determine the product’s actual effectiveness against facial wrinkling.

Argireline® is effective active agent in our Anti-Wrinkle 55 Gold Serum along with other top ingredients such as Hyaluronic Acid and Aloe Vera Leaf Juice.

The application of Argireline® is simple. Argireline is marketed specifically as a “topical alternative to Botulinum Toxin A,” which is the surgical procedure usually marketed under the trade name Botox® (which is injected via a needle). As such, it is an anti-wrinkle treatment.

Argireline® works in the biological pathways of the skin cells by mimicking and destabilizing the SNAP-25 receptor complex essential for muscle contraction, thereby modulating its formation.

It also acts to inhibit or slow the release of catecholamine in chromaffin cells; excessive catecholamine buildup is also thought to contributes to wrinkles. If the SNARE complex is slightly destabilized, the vesicle cannot dock and release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.

With the Botulinum Toxin - Botox® - , it is injected directly into a specific muscle to stop contraction. This procedure was initially performed to stop problems such as permanently crossed eyes or spastic blinking. If they could stop specific muscle (responsible for the eye crossing/blinking) from contractions, the eye would not cross/blink. A positive side-effect from such procedures was the observation that fine wrinkles were disappearing.

Today, Argireline® offers a non-invasive technique to achieve similar results. Argireline® (Acetyl Hexapetide-8) – used in anti-aging products such Anti Wrinkle 55 Gold Serum - is applied to the eyes, forehead and to other areas of the face. It works by interrupting neurotransmission that tells the muscles to contract. If the muscles don’t contract, wrinkles are not formed. It’s just that simple – and safe.

For maximum results, I recommend using Supreme Peptide Cream 6 Quadruple-Action Formula (Matrixyl 3000) (daily after applying Anti-Wrinkle 55 Gold Serum) for Collagen development..

Think Exfoliate – Reduce Wrinkles – Stimulate Collagen.


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**The text contained in this web site is for informational purposes and is not meant to be a substitute for the advice provided by your own physician, dermatologist or medical professional. The information contained herein is not intended for diagnosing or treating a health problem or disease. Information and statements regarding cosmetic grade products are not evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Customers' reviews/testimonials may be provided for information purposes related to the effectiveness of Sarah's Age Defying Secrets products, however, results vary from person to person.